Postdoctoral Fellow
Harvard Medical School
Emmanuel C. Ogbonna, PhD
Harvard Program in Therapeutic Science (HiTS),
Harvard Medical School, Boston, Massachusetts.
My research is on the pathogen Mycobacterium tuberculosis. I had previously studied putative targets for novel TB drugs, including essential cellular proteases. I am currently studying the relationship between granuloma heterogeneity and host immune response – elicited upon tuberculosis infection – using tissue cyclic immunofluorescence or t-CyCIF. CyCIF is used with a wide array of antibody markers to phenotype all the different cell types associated with the granuloma stages, especially their spatial relationships to one another. With these cell-cell associations assessed, it is then possible to understand physiological and immunological outcomes in the TB granuloma microenvironment.