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Karen M. Puopolo, MD, PHD (she/her/hers)

Professor of Pediatrics
Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine
Swarthmore, PA, United States

Karen M. Puopolo, M.D., Ph.D. is a neonatologist who specializes in neonatal infectious diseases. Dr. Puopolo is a Professor of Pediatrics on the faculty of the University of Pennsylvania Perelman School of Medicine. She is a member of the Division of Neonatology at The Children’s Hospital of Philadelphia, and Section Chief for Newborn Medicine at Pennsylvania Hospital. Dr. Puopolo received her undergraduate degree in physics from Yale University, and her M.D. as well as a Ph.D. in molecular physiology from the Tufts University School of Medicine and Graduate School of Biomedical Sciences in Boston, Massachusetts. She completed Pediatric residency and Neonatal-Perinatal fellowship training at Boston Children’s Hospital. Upon completing fellowship, Dr. Puopolo was appointed to the faculty of Harvard Medical School and joined the staff of the Brigham and Women’s Hospital and the Channing Laboratory, where she was an attending neonatologist and investigator from 2000-2014. Dr. Puopolo began her neonatal research career as a laboratory-based scientist investigating mechanisms of virulence in Group B Streptococcus. More recently her research has focused on the epidemiology of neonatal infection, with an emphasis on risk assessment and antibiotic stewardship. In collaboration with Dr. Gabriel Escobar, she developed the Neonatal Early-Onset Sepsis Calculator, a clinical decision tool for sepsis risk assessment among term infants. Dr. Puopolo is an active member of the American Academy of Pediatrics (AAP), contributing to practice guidance for neonatal sepsis, GBS prevention, perinatal COVID-19 and neonatal antibiotic stewardship. She has served as faculty for the neonatal quality collaborative Vermont-Oxford Network and is a member of the editorial boards for Pediatrics and Pediatric Research. In 2022, Dr. Puopolo received the AAP Pennsylvania Chapter Pediatrician of the Year award.

Disclosure(s): No financial relationships to disclose

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