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Thea Brennan-Krohn, MD, D(ABMM) (she/her/hers)

Assistant Professor of Pediatrics and Pathology
Harvard Medical School
Boston, MA, United States

Dr. Brennan-Krohn is a physician-scientist whose research is focused on novel approaches to diagnosis and treatment of multidrug-resistant gram-negative bacterial infections. She completed a Pediatrics Residency at the Boston Combined Residency Program, a Pediatric Infectious Diseases fellowship at Boston Children’s Hospital, and a Clinical Microbiology fellowship at Beth Israel Deaconess Medical Center (BIDMC). Her post-doctoral fellowship work, in the lab of James Kirby, involved investigation of antimicrobial synergy to identify regimens in which antibiotic activity could restored when drugs were used in combination against multidrug-resistant organisms. In addition to research, she spends time seeing patients on the Infectious Diseases service at Boston Children’s Hospital and serving as an attending physician in the Clinical Microbiology Laboratory at BIDMC.

The Brennan-Krohn laboratory at BIDMC is dedicated to carrying out translational research investigating the effects of antibiotic exposure on gram-negative bacteria, with the goal of identifying optimal treatment approaches for different types of complex, drug-resistant infections. Particular areas of interest include investigation of the activity of antibiotics against Burkholderia cepacia complex (Bcc) organisms in artificial sputum medium to understand activity in the lungs of people with cystic fibrosis, a high-throughput screen of antibiotic potentiators for Bcc, and studies of the mechanisms of activity and of bacterial resistance to novel non-beta-lactam beta-lactamase inhibitors.

Disclosure(s): No financial relationships to disclose

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