Associate Professor of Medicine, Molecular Genetics and Microbiology
Duke University School of Medicine
Dr. Thuy Le is an Associate Professor of Medicine, Associate Professor of Molecular Genetic and Microbiology at Duke University School of Medicine and an Associate Director of the Clinical Core of the Duke Centre for AIDS Research. She leads an international research program spanning Vietnam, China, and Myanmar to reduce morbidity and mortality in patients with advanced HIV disease. Her research focuses on developing and testing novel diagnostics and therapeutics for talaromycosis and other HIV-associated mycoses. She led as PI the first ever randomized treatment trial for talaromycosis (IVAP) that demonstrates a mortality benefit of amphotericin B over itraconazole as induction therapy which has directly informed treatment guidelines around the world. She is now funded by the NIH to evaluate a novel antigen detection assay for early diagnosis and for screening asymptomatic talaromycosis in Vietnam. Her passion and experience in the translation of knowledge and technology to advance diagnosis, treatment, and prevention have placed her at the forefront of international leadership in both the medical mycology and the HIV fields. She serves on numerous WHO Treatment Guidelines and Review Committees on global HIV management and management of advanced HIV disease, cryptococcal meningitis, and histoplasmosis. She leads the talaromycosis guidelines for the NIH/CDC/IDSA Guidelines Committee for HIV-associated opportunistic infections and she coordinates the development of the European Confederation of Medical Mycology Guidelines on Diagnosis and Treatment of endemic mycoses. She is an Associate Editor of Medical Mycology and of PLOS Neglected Tropical Diseases.